FORMULATION AND EVALUATION OF BIOADHESIVE OFLOXACIN HYDROCHLORIDE NIOSOMAL DISPERSION FOR EYE INFECTION

Sheik Rishan*, Dr. Krishnananda Kamath K. and Dr. A. R. Shabaraya

ABSTRACT

Ocular drug delivery is a very challenging task faced by pharmaceutical scientists, inspite of the fact that eye is the most sensitive and accessible organ for the delivery of drugs. A major disadvantage associated with conventional dosage form is its low bioavailability, that is less than 10%. To improve the bioavailability, viscosity-enhancing agents or mucoadhesive polymers are used for treating severe ocular diseases. These polymers play an important role in increasing the precorneal residence of drug at ocular site. Ofloxacin eye drops were frequently used for the treatment of infectious eye. However, such formulations have a major drawback, that is short duration of action and usually require 4-6 times instillation daily. A bioadhesive polymer coated niosomal formulation of Ofloxacin was supposed to show a longer retention time on eyes and subsequent reduction in dosing frequency. The current study revealed that bioadhesive niosomal formulations enhances the ocular retention time and have sustained drug release into the eye.

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