DEVELOPMENT AND CHARACTERIZATION OF FAST DISSOLVING TABLETS OF ANTI-HYPERTENSIVE AGENT BY USING DIFFERENT SUPERDISINTEGRANTS

Gurjeet Singh*, Varinder Soni, Lakhvir Kaur, NupurAnand, Disha Singh, Amritpal Kaur and RK Dhawan

ABSTRACT

Timolol maleate is a nonselective β- adrenergic blocker and it blocks both β-1 and β-2 adrenergic receptors to reduces blood pressure decreasing sympathetic outflow. The main object of this research work was to formulate the fast dissolving tablets of Timolol Maleate by direct compression technique using croscarmellose sodium as superdisintegrant. The FTIR compatibility studies for drug and excipient were subjected. The result indicated no interaction between drug and carriers. Fast dissolving tablets should give fast disintegration, dissolution, ease to swallowing, and gives quick onset of action. The prepared blends were evaluated and analyzed by using various parameters such as bulk density, tapped density, and angle of repose. The prepared tablets were evaluated for tablet thickness, tablet hardness, wetting time, disintegration time, and friability.

Keywords: Timolol Maleate, Direct Compression Technique, Croscarmellose Sodium, Fast dissolving tablets.