CATHEPSIN INHIBITION BY SMALL PEPTIDES

Nishat Chowdhury*, Shingo Ueno and Yuki Mochizuki

ABSTRACT

Background: Previous paper results indicate that small peptides can be found from DNA translation. Translated peptides can be tested against enzymes like cathepsin having both positive and negative effect on cancer cells. Material and methods: DNA reaction and organic synthesis of DNAs that translate small peptides, cell viability assay etc. were performed. Results: 3 novel peptides found which inhibits Cathepsin enzyme in MDA-MB-231 and MCF-07 breast cancer cells.

Keywords: MCF-07, MDA-MB-231, Breast cancer.