EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

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Abstract

STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION OF TOPIRAMATE USING RP-HPLC IN BULK AND PHARMACEUTICAL DOSAGE FORMS

*Ranjana Kumari, Shyamala and Dr. J. V. C. Sharma

ABSTRACT

The present project work is aimed on stability indicating method development and validation of topiramate using RP-HPLC in bulk and pharmaceutical dosage form . The method developed will be accurate, precise and linear for the estimation of the drugs in the near future. The analytical method will be developed by studying different parameters of Topiramate. The column used for study is Inertsil C18, ODS chosen good peak shape. Ambient temperature is found to be suitable for the nature of drug solution. The flow rate will be fixed at 1.0ml/min to obtain good peak area, satisfactory retention time and good resolution. Different ratios of mobile phase will be studied, mobile phase with satisfactory results will be selected for good symmetrical peaks and good resolution. We conduct the analysis based on UV detection and Reverse Phase High Performance Liquid Chromatograph.

Keywords: Topiramate, RP-HPLC, UV spectrometer.


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SJIF Impact Factor: 7.065

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