THE ANTAGONIST-TUBERCULOSIS DRUG WHICH INDUCES HEPATOTOXICITY IN A GERIATRIC PATIENT IN TERTIARY CARE HOSPITAL: A CASE REPORT

G. Venkata Naveen Kumar*, N. Doondi Phani Kumar, Sk. Mohammed Firdoz, A. Pravalika

ABSTRACT

Combination therapy is crucial for the short-term course of contrary-Tuberculosis treatment, It affirms the development the imperilling of Anti-TB drug-induced liver damage, Hepatocellular injury represented by a gradual increase in the aminotransferases in serum which precede elevations in total bilirubin levels and alkaline phosphatase levels. A 75yrs male subject to a tertiary care hospital with complaints of diminished appetite and generalized weakness for two days. History of type two diabetes mellitus for five years on insulin therapy and right pyopneumothorax with bronchopleural fistula, extensive pleural effusions, pulmonary Koch on Contrary-Tubercular Therapy (ATT) for one month. I formed a provisional conclusion as a contrary-tubercular drug (levofloxacin) induced hepatitis. Doctors should remain mindful that levofloxacin can cause hepatotoxicity in subtle incidents. it would be for physicians to remain conscious of the risk of levofloxacin-induced hepatotoxicity.

Keywords: Anti-tuberculosis drugs, levofloxacin-induced hepatotoxicity.