A REVIEW ON SOLID LIPID NANOPARTICLES

Abhishek S.*, Vedamurthy Joshi, Nagesh C. and Rajeshwari A. G.

ABSTRACT

Formulations using Solid lipid nanoparticles (SLN) are promising area of nanotechnology with significant applications in various fields like Novel drug delivery, clinical medicine and pharmaceutical research due to their unique size dependent properties in the development of drug therapy. These different substances have been entrapped into lipid Nano-particles, extending from lipophilic and hydrophilic molecules, including labile compounds, such as proteins and peptides. SLN are with a nanometer range can protect the drug in contradiction of in-vitro and in-vivo degradation and it release the drug in controlled way and also offers the possibility of drug targeting. The different production methods which are suitable for large scale production and applications of solid lipid nanoparticles are defined. The present review focuses on the utility of SLN in terms of their advantages, production methodology, characterization and applications.

Keywords: Solid lipid nanoparticles, Advantages, Preparation and Characterization.