ENHANCEMENT OF BIOAVAILBILTY OF RIFABUTIN BY MELT GRANULATION METHOD

Jyoti Maithani*, Prof. (Dr.) Ranjit Singh, Prof. Dr. Sanjay Singh and Prof. Dr. Kapil Kalra

ABSTRACT

This work describes a melt granulation technique to improve the solubility and dissolution characteristics of a poorly water-soluble drug, Rifabutin. Melt granulation technique is a process by which pharmaceutical powders are efficiently agglomerated by a meltable polymers and surfactants. Granules were prepared by using polymer like different grades of polyethylene glycol and surfactant like different grades of poloxomers. The granules were characterized using powder DSC, XRD and FTIR techniques. A significant enhancement in the in vitro dissolution profiles of the melt granules was observed compared to the pure drug and drug excipient physical mixtures. DSC results indicated change in internal energy of Rifabutin with polymers and surfactant in the melted granulated. In conclusion, the results of this work suggest that melt granulation is a useful technique to enhance the solubility and dissolution rate of poorly water-soluble drugs, such as Rifabutin.

Keywords: Rifabutin, melt granulation, Solubilty enhancement.