STUDY THE POLYMER ABSORPTION ON PHYSICAL EFFECT AND DRUG RELEASE OF DICLOFENAC SODIUM MICROSHPERES.

Poonam Joshi*, Jyoti Maithani, Prof. (Dr.) Kapil Kalra, Dr. Lokesh Tyagi and Sapna Rawat

ABSTRACT

Diclofenac sodium is a potent non-steroidal drug with potent analgesic and anti-inflammatory activity. Its oral administration is associated with a high risk of adverse effect such as irritation, ulceration and bleeding of gastrointestinal tract. The present study focuses on the development of controlled release drug delivery system of diclofenac sodium. Diclofenac Sodium microspheres were prepared successfully using the solvent evaporation method. Polymer: drug ratio influenced the physicochemical properties microspheres. From the experimental results it can be concluded that biocompatible and cost-effective polymers like ethyl cellulose can be used to formulate an efficient microparticulate system with good percentage entrapment efficiency and practical yield. The ratio of polymer in dispersion medium was the controlling factors of microsphere micrometric parameters and drug release. Higher percentage of drug loading was obtained by increasing the concentration of polymer. The microspheres showed good flow properties and packing ability, indicating that it can be successfully handled and filled into a capsule dosage form. The particle size of a microsphere was determined by optical microscopy and all the batches of microspheres show uniform size distribution. It was observed that with increase in polymer concentration, the mean particle size of the microspheres increased. The in-vitro dissolution studies showed that Diclofenac Sodium microspheres formulation F4 showed better sustained effect (94%) over a period of 8 hours than other formulations.

Keywords: Microsphere, diclofenac sodium, calcium chloride, solvent evaporation method, ethyl cellulose.