EVALUATION OF ANTI DIABETIC ACTIVITY OF MAERUA OBLONGIFOLIA IN STREPTOZOTOCIN – NICOTINAMIDE INDUCED TYPE – II DIABETIC RATS

Mandha Nagamani*, Bollapalli Priyanka, Kandula Sharanya, Mamidala Vamshikrishna

ABSTRACT

The term diabetes mellitus describes a metabolic disorder of multiple etiology characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action or bot.Freshly prepared Maerua oblongifolia extract was subjected to phytochemical screening tests for the detection of various constituents using conventional protocol. The effects of diabetes mellitus include long-term damage, dysfunction and failure of various organs. The extract treated groups showed greater persistence of the islets and less degree of necrotic changes when compared to the diabetic rats. Test extracts showed the anti-diabetic activity by acting as an insulin secretogogue. In present study we can conclude that aerial parts of Maerua oblongifolia at doses 200mg/kg and 400mg/kg showed significant reduction in glucose, lipid profile, liver enzymes, body weight .While in increasing insulin secretion and decreasing the levels of glycosylated haemoglobin, postprandial glucose a dose of 400 mg/kg shows good activity. Maerua oblongifolia at doses 400 mg/kg potentiated insulin secretion from surviving β- cells. Pancreas histopathology shows improvement in the histology of the islets of Langerhans upon treatment with extract.

Keywords: Maerua oblongifolia, Extraction, Anti Diabetics.