ANTILEISHMANIAL ACTIVITY AND COMPUTATIONAL STUDIES OF SOME HYDRAZONE DERIVATIVES POSSESSING QUINOLINE NUCLEUS

Essa Ajmi Alodeani, Mohammad Arshad*, Mohammad Asrar Izhari

ABSTRACT

Antileishmanial activity of the previously synthesized hydrazone derivatives 1-3 was evaluated in vitro on a culture of Leishmania donovani promastigotes (Strain S1). The results were compared with the standard drug Amphotericin B. out of all, compound three was found to possess good activity when compared to the standard drug. Physicochemical properties and bioactivity score studies were carried out using Lipinski’s rule of five, Molinspiration (web based software). The results of computational studies were found in accordance with the results obtained experimentally. All compounds were found to follow Lipinski’s rule of five with the bioactivity score better than standard.

Keywords: Antileishmanial activity, hydrazone derivatives and computational studies.