FORMULATION AND EVALUATION OF TELMISARTAN LOADED ETHOSOMAL PATCH

Vemula Vaishnavi*, I. Bala Tripura Sundari and Dr. M. Bhagavan Raju

ABSTRACT

The aim of the present study was to develop telmisartan loaded ethosomal patch to improve bioavailability of telmisartan by avoiding the first pass metabolism. Ethosomes are lipid vesicular carriers containing ethanol which provides better penetration of drug in to skin. Telmisartan ethosomes were prepared by cold method (30°C), using different ratios of egg lecithin, cholesterol and ethanol. The formulated ethosomes were evaluated for all the physicochemical parameters such as particle size, zeta potential, SEM, entrapment efficiency and drug release. The best selected ethosomal formulationF11 showed an entrapment efficiency of 85% and drug release of 83.89% in 6hrs.The best selected ethosomal formulation of telmisartan was used to prepare ethosomal patch by using Hydroxy Propyl Methyl Cellulose (HPMC E15) as a film forming agent and dibutyl phthalate as a plasticizer. All the developed ethosomal patches of Telmisartan were evaluated for folding endurance, drug content, weight variation and in-vitro drug release. The in-vitro drug release was found to be 92.56% over a period of 24 hours. Based on the above results it can be concluded that administration of telmisartan ethosomes through transdermal route is a better approach.

Keywords: Telmisartan, ethosomes, ethosomal patch.