OVERVIEW OF DIFFERENTIATION OF MESENCHYMAL DERIVED STEM CELL INTO INSULIN PRODUCING CELLS AND THEIR CLINICAL ISSUES IN TRANSPLANTATION
Prabhu N.*, Nivedha S., Aparna M. T., Angel Romila K. and Jeyavel Karthick P.
ABSTRACT
Diabetes mellitus is one of chronic disorder it has various subclasses such as type 1diabetes which is insulin dependent, gestational diabetes and type 2diabetes. At present there is no proper therapeutic drug for the cure of diabetes. Transplantation of the differentiated stem cells which are derived from adipose tissue, bone marrow, placenta, umbilical cord, dental pulp etc. but the transplantation may also lead to rejection. This review article explains different types of mesenchymal derived stem cells that differentiated into insulin producing cells and clinical issues in their transplantation.
Keywords: Mesenchymal stem cells, chronic disorder, transplantation, clinical issues.
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