FORMULATION, EVALUATION AND CHARACTERIZATION OF FLOATING TABLET OF AZITHROMYCIN FOR HELICOBACTOR PYLORI

Neha Arora, Yogesh Matta, Dr. Sonu Sharma, Saurabh Sharma, Sandeep Singh, Md Dabeer Ahmad

ABSTRACT

Oral route has been the most popular and successful route used for controlled delivery of drugs. Controlled release of drug delivery system (CRDDS) optimizes the biopharmaceutical, pharmacokinetic, pharmacodynamic, properties of drugs and to reduce the side effects and to designed to deliver the drug in such a way that the levels are maintained within the therapeutic window effective for a long period till the system continuous to deliver the drug at a particular rate. In present study, an attempt was made to formulate floating tablet of Azithromycin in order to enhance bioavailability, reduce dose thereby improve patient compliance. Preformulation studies were done to characterize the chemical and physical properties of drug. FT-IR spectrum and melting point determination confirmed identity and purity of Azithromycin. Azithromycin was subjected to compatibility studies with different excipients, there was no physical change observed in drug and excipients. Further, it was confirmed by taking FT-IR graphs.

Keywords: Azithromycin, Excipients, Pharmacokinetic, Pharmacodynamic, Bioavailability.