DESIGN, SYNTHESIS, MOLECULAR DOCKING AND BIOLOGICAL EVALUATION OF SOME NEW THIOPHENE DERIVATIVES AS ANTI-CANCER AGENTS

Mokhtar Abd-Hafiz Al-Ghorafi*, Aliaa Mohammed Kamal, Jalal H. Abdullah, Tawfeek Ahmed Ali Yahya, Shada H. Yassin

ABSTRACT

Structure-based design, synthesis and biological evaluation of newly synthesized small molecules anti-cancer agents were described. On continuation of applying scaffold hopping theory, a series of substituted 2-amino, 3-cyanothiophene based on the structural features of Sorafenib was designed, synthesized and evaluated as cytotoxic agents against MCF7 and HCT 116 cell lines. Substituting the amino group of 2-aminothiophene with different pharmacophoric groups led to discovery of two potent lead compounds IIIb and IIIc with excellent cytotoxic activity against MCF7 and HCT 116 cell lines.

Keywords: nti-Cancer Agents; Angiogenesis; VEGFR-2; Thiophene Derivatives and Structure-based Drug Design.