CYTOKINE PROFILE IN CHILDREN WITH CONGENITAL CLEFT LIP AND PALATE

*Musakhodjaeva D. A. and Sharopov S. G.

ABSTRACT

Background: It was found that in recent years all over the world is progressively increasing the number of children with congenital malformations, including the face and jaws. The problem of changing the state of the immune system in children with ССULaP little studied. In postnatal adaptation of the immune system of newborn children by one of the leading mechanisms is the activation of cytokine system, which play an important role in protecting, launching immune processes. Objective: The study of the role of serum cytokines and their diagnostic significance in children with congenital cleft lip and palate to support new approaches to rehabilitation and prevention of complications at various stages of treatment. Methods: The material for the research was the peripheral blood of 210 children with congenital cleft lip and / or palate, are at different stages of surgical treatment at the Department Children's Maxillofacial Surgery Regional Hospital of Bukhara. Sick children were 3 groups depending on the type of cleft: 1st group - 55 children with congenital cleft upper lip, 2nd group - 75 children with congenital cleft palate and third group - 80 children with congenital cleft lip and palate. Result: Thus, it is shown pathogenetic role and diagnostic value of the studied cytokine (IL-4, IL-6, IL-18 and MCP-1) in children with congenital cleft lip and palate, the severity of which can be a criterion for the degree of violation remodeling process bone, that must be considered when carrying out surgical treatment in this group of children

Keywords: Children, congenital cleft lip and / or palate, cytokines.