CLINICAL STUDY TO EVALUATE THE EFFICACY & SAFETY OF CURCUMIN CAPSULE IN PATIENTS WITH COUGH DUE TO CHRONIC BRONCHITIS

*Dr. Harisha S.

ABSTRACT

Background: Bronchitis is a term that describes inflammation of the bronchial tubes (bronchi and the smaller branches termed bronchioles) that results in excessive secretions of mucus into the tubes, leading to tissue swelling that can narrow or close off bronchial tubes. Bronchial tubes extend from the trachea and terminate at the alveoli in the lungs. The bronchial system resembles an inverted tree and is sometimes termed the "bronchial tree." A few authors include the trachea and upper airway in the definition of bronchitis. There are two major types of bronchitis, acute and chronic. Chronic bronchitis differs from acute bronchitis in several ways, for example, pathology, progression of disease, major causes, treatments, and prognosis. Recurrent incidences of acute bronchitis are the first steps that can lead to developing chronic bronchitis, according to some doctors and researchers. Chronic bronchitis is defined as a cough that occurs every day with sputum production that lasts for at least 3 months, two years in a row. This definition was developed to help select uniform patient populations for research purposes, for example, to study medication therapies for treatment of chronic bronchitis. Objectives: To assess the efficacy and safety of Curcumin capsule in Patients with cough due to Chronic Bronchitis. Conclusion: The study concludes that, TEST (CURCUMIN) due to its anti-inflammatory and immunomodulatory effect it is more efficacious and safer in comparison to PLACEBO (B) in treatment of cough due to chronic bronchitis and also alleviating the symptoms of chronic bronchitis along with improvement in immunity.

Keywords: Forced Expiratory Volume-One Second (FEV1).