THE ROLE OF CYTOKINES IN PATHOGENESIS, DIAGNOSTICS, AND PROGNOSIS CERVICAL NEOPLASIA

*Kalandarova Amina Nurullayevna

ABSTRACT

Background: It is generally recognized that the problem of cervical tumors is associated not only with a persistently high incidence of cancer, but also with the difficulties in diagnosing cervical intraepithelial neoplasia, which is one of the stages of malignancy of cervical epithelium. Objective: A prospective study was conducted of 177 patients with cervical intraepithelial neoplasia of the cervix uteri who were examined. Methods: Determination of the concentration of cytokines IL-1β, TNF-α, TGF-β in cervical mucus was carried out using standard commercial ELISA kits. Result: The obtained data convincingly indicate a pronounced imbalance of the cytokine regulation of the mechanisms of immune control of cell homeostasis against the background of viral infection, which determines the formation and progression of neoplastic lesions of the cervix. Conclusion: Clinical and morphological factors for the prognosis of cervical intraepithelial neoplasia and cervical cancer have a direct correlation with infection of the cervix, production of cytokines.

Keywords: Cervical intraepithelial neoplasia, immunity, cytokines.