EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR-? (PPAR-?) AGONIST INDUCE SENSITIZATION ?1 ADRENERGIC RECEPTOR VIA REGULATION EXTRACELLULAR SIGNAL-REGULATED KINASE 1/2 (ERK 1/2) AND G PROTEIN-COUPLED RECEPTOR KINASE-2 (GRK-2) IN CULTURE CARDIOMYOCYTE

Rachmat Hidayat* and Patricia Wulandari

ABSTRACT

The present study evaluated effect of pioglitazone (PPAR γ agonist) to sensitize β1-adrenergic receptor in culture cardiomyocyte. Up-regulated GRK2 and down-regulated of β1-adrenergic receptor in the heart underlies the diminished contractile responsiveness of the heart to positive inotropes. The result of study showed that potention of pioglitazone to increase or sensitize β1-adrenergic receptor via increase ERK1/2 and decrease GRK-2. The potention pioglitazone to increase concentration of β1-adrenergic receptor not only based on dose-dependent of pioglitazone but also influenced by concentration of norepinephrine.

Keywords: Pioglitazon – PPAR ? Agonist – ?1 adrenergic – GRK2 – ERK1/2.

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SJIF Impact Factor: 7.065

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New Issue Published
Its Our pleasure to inform you that, EJPMR 1 November 2024 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

EJPMR: NOVEMBER ISSUE PUBLISHED
NOVEMBER 2024 issue has been successfully launched on 1 NOVEMBER 2024.

EJPMR New Impact Factor
EJPMR Impact Factor has been Increased to 7.065 for Year 2024.

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EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH