ANTIDIABETIC ACTIVITY OF COCCINTIA GRANDIS IN ALLOXAN INDUCED DIABETIC RATS

Shubham G. Suryawanshi*, Kalyani R. Shinde, Prof. P. N. Folane, Prof. S. L. Khedekar and Prof. S. D. Sagrule

ABSTRACT

Diabetes mellitus is lifestyle disease rapidly spreading in India. It has been major health issue in south-east Asia and world’s largest numbers of diabetics are found in India. By 2019, 60.8 million diabetics arefound and this will rise up to 97 million by 2030. Therefore looking at the scenario and possible complications of uncontrolled B.G.L, different modes of therapy have been practiced. The present work is an effort to study Antidiabetic’s activity of coccintia grandis in alloxan induced diabetic rats. Coccintia grandis is commonly known as Gram (ivy gourd. Family- CCucurbitaece). A single dose of (150 mg/kg) alloxan prepared in normal saline solution was injected intraperitonially to induce diabetes in rats. The age matched control rats receives an equal volume of citrate buffer and used along with diabetic animals. Diabetes was confirmed after 48 hr of alloxan injection.The rats having plasma glucose level more than 300 mg/dl were selected and study was conducted for 21 days. The rats were divided into six groups and serum glucose levels were assessed by GOD - PAP method. The BGL and body weights were taken at day 1, day 3, day 7 and day 21.This investigation proves that coccintia grandis shows beneficial effect in diabetes. It is found to reduce the BGL and prevented loss of Body weight in diabetic rats and does not have any effect on normal glycemic level. Thus, it can be concluded that coccintia grandis can be used as supportive therapy for diabetes mellitus.

Keywords: Alloxan, Antidiabetic, 5% Glucose, Metformin, Ethanol.