THE CORRELATION BETWEEN XANTHINE OXIDASE, LACTATE DEHYDROGENASE AND NITRIC OXIDE LEVELS IN SERA OF PATIENTS WITH MINOR ?-THALASSEMIA

*Namama Soran. H., Govand Ali A. and Dlzar D. Ghafoor

ABSTRACT

In the present study, 55 patients with β-Thalassemia minor aged between (9-45 years) and 35 apparently healthy controls aged between (8-40 years) were investigated for Xanthine Oxidase (XO), Lactate dehydrogenase (LDH) activities and Nitric Oxide (NO) level. Correlation between XO, LDH activity and NO levels has been studied to select the best characteristic marker to identify β-thalassemia minor patients and to investigate the relationship between these markers with β-thalassemia minor subjects. The results showed a significant increase in XO, LDH activity and a significant decrease in NO levels compared to control group while no correlation has been noticed between XO, LDH activity and NO levels in both patients and healthy subjects.

Keywords: ?-thalassemia, Xanthine Oxidase, Lactate Dehydrogenase, Nitric Oxide.