PREVALENCE AND ASSESSMENT OF ANTIBIOTIC SUSCEPTIBILITY PROFILES OF COAGULASE-NEGATIVE STAPHYLOCOCCI ISOLATED FROM CLINICAL SAMPLES.

*Olajubu, F. A. and Deji-Agboola, A. M

ABSTRACT

Background: Persistent increase in Microorganisms’ resistance to available antibiotics has become a global concern. The changing role of many microorganism from non-pathogenic normal body flora to pathogenic strains increases the need for regular surveillance of antibiogram profile of clinical isolates. This study was designed to investigate the prevalence and susceptibility pattern of Coagulase-Negative Staphylococci (CoNS) in Sagamu area of Ogun State, Nigeria. Materials and Methods: This 5-year retrospective study covered between 2011 and 2015 with 115 coagulase negative staphylococci isolated. The isolation, identification, assessment for methicillin resistance and susceptibility testing of the isolates followed the standard methods of Clinical Laboratory Standard Institute (CLSI). Results: CoNS were isolated from 72 females and 43 male patients with 30.4% isolated from Urine samples. The highest number of CoNS (34) was isolated in 2014 while the lowest (14) in 2012. Seventy-three (63.5%) of the CoNS isolates were screened methicillin resistant (MRCoNS). All the MRCoNS were resistant to Penicillin, 84.9% to Cephalexin and 28.8% to Gentamycin. No resistance against Ciprofloxacin among MSCoNS but 71.2% among MRCoNS. Multidrug resistance was observed among the two groups of CoNS. Conclusion: The importance of continous monitoring of the antibiogram of CoNS cannot be overemphasized. This study will provide the needed guide for clinicians in antibiotic selection and formulation of antibiotic policy to curb spread of resistant strains.

Keywords: Coagulase-Negative Staphylococci (CoNS), Sagamu, Retrospective study, Methicillin Resistance CoNS, MSCoNS.