COMPARATIVE ANALYSIS OF ANTIOXIDANT POTENTIAL AND ANDROGRAPHOLIDE CONTENTS IN ANDROGRAPHIS PANICULATA (L.) NEES AND ANDROGRAPHIS ECHIOIDES (L.) NEES

Venkatachalam Vigneshwaran, Balasubramanian Muthusamy and *Girija Shanmugam

ABSTRACT

Andrographis paniculata and Andrographis echioides are well-known species of Indian and south Asian traditional medicines. Andrographis paniculata (AP) commonly known as Nilavembu is recently, attracted as a valuable therapeutic plants for treating Dengue fever. Andrographis echioides (AE) is a closely related species of Andrographis paniculata. Hence, the phytochemical contents was screened and compared between the two species. In the present investigation, protocols for methanolic extract of in vivo plant parts like leaf, stem, root, have been standardized. Maximum percentage of Andrographolide was obtained in both the species. Andrographis echioides. Methanolic extracts of both plant parts (leaf, stem, and root) have showed antioxidant activity in DPPH, FRAP, ABTS, H2O2, reducing power, metal chelating efficiency with little variation. Similarly, Andrographolide contents were also varied among the plant parts of two species where maximum content was present in leaf (381.72 mg/g DW) of AP and 347.93mg/g DW in stems of AE.

Keywords: Andrographis paniculata and Andrographis echioides.