EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

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Abstract

SYNTHESIS, MOLECULAR DOCKING AND ANTIDIABETIC ACTIVITY OF SOME SULPHONAMIDE BEARING QUINAZOLINONE MOIETIES

Shweta S. Gaikwad*, Shailaja B. Jadhav and Deepti D. Banadawane

ABSTRACT

Type 2 diabetes (T2D) is a lifestyle disease affecting millions of people worldwide. Herein, the design and synthesis of 17 novel quinazolinone incorporating sulphonamide scaffold are described. Designed compound were docked using AutoDock (4.2.6) tool software with DPP-IV inhibitor protein (PDB: 3OPM). Synthesized compounds (4a-q) were evaluated for antidiabetic activity in streptozotocin-nicotinamide induced diabetic rats. Most of these synthesized compounds showed significant reduction in blood glucose level. Amongst all the compounds designed in this study, we identified compound 4q as a potent, selective and orally active antidiabetic agent, which exhibited in vivo efficacy in diabetic rat model.

Keywords: Antidiabetic agents, Quinazolinone, Sulphonamide, Type 2 Diabetes.


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  All Since 2019
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