SELF-EMULSIFYING DRUG DELIVERY SYSTEM - A NOVEL APPROCH TO IMPROVE ORAL BIOAVAILABILITY

Swati Lade*, Umesh Telrandhe, Sushil Burle, Satish Kosalge

ABSTRACT

The oral route is the most favorite route of drug delivery for cure of a number of diseases. It is estimated that 35-40% of active substances are poorly soluble in water. The major problem in oral drug formulations is low and erratic bioavailability, which mainly results from poor aqueous solubility. The improvement of bio-availability of drugs with such properties presents one of the greatest challenges in drug formulations. Various technological strategies are reported in the literature including Micronization, solid dispersions or cyclodextrines complex formation and different technologies of drug delivery systems. SEDDS are promising advance for oral delivery of poorly water-soluble compounds or lipophilic drugs. SEDDS are ideally isotropic mixtures of drug, oil, surfactant and/or co surfactant. Purpose of this review article is to provide brief outline of self emulsifying drug delivery system & it‟s possible to increase the bioavailability of poorly soluble drugs.

Keywords: Self-emulsifying drug delivery systems (SEDDS), drug delivery, Surfactant; Co Surfactant; bioavailability.