ASSESSMENT OF ADVERSE DRUG REACTIONS OF DRUGS USED IN TERTIARY CARE TEACHING HOSPITAL

Dr. Virendra Kushwaha, *Dr. Pooja Agrawal, Dr. Mangeshkumar Tripathi, Mr. Sumit Kumar

ABSTRACT

Objective: The purpose of this study was to assess the incidence and pattern of adverse drug reactions reported from different department of Tertiary care hospital. Methods: The reports of ADRS were recorded as per the standard guidelines of Pharmacovigilance programme of India (PvPI). Causality, Severity and Types of ADR was assessed by using Naranjo Probability scale, Modified Hartwigs criteria and Rawlins &Thompson classification respectively, Seriousness of ADR was assessed by criteria given by WHO. Results: A total 146 ADRs were reported from 126 patients. Majority of the ADRs were Type A reactions, Highest incidence 65.06% of ADRs was observed between (31-60) years of age, 61.11% of patients were female and 38.88% were male. In the assessment of severity mild and moderate were 99.31% and 0.68% respectively and causality assessment 86.98% were probable, 12.32% possible and 0.68% Unlikely. Conclusion: A careful attention is needed in monitoring and reporting of ADR because most of drugs have ADRs and in our country ADR reporting is in growing phase. There is need of more work on spontaneous reporting and awareness among health care Professional and practitioner to report all the adverse drug event to Pharmacovigilance center.

Keywords: Adverse Drug Reactions, Pattern of ADR, Pharmacovigilance, ADR Monitoring.