SYNTHESIS OF POLYHYDROQUINOLINES USING PHENYL PHOSPHONIC ACID AS CATALYST

Sanjeev M. Reddy and Jitendra S. Pulle*

ABSTRACT

A facile and efficient method has been developed for the one pot synthesis of polyhydroquinolines via four component reaction of ethyl acetoacetate, aldehyde, dimedone and ammonium acetate in the presence of catalytic amount of phenyl phosphonic acid in ethanol through Hantzsch reaction. The method described herein is simple, environmentally benign and provides good yields of the products.

Keywords: Polyhydroquinolines, phenyl phosphonic acid, ethyl acetoacetate, aldehyde, dimedone.