A SENSITIVE ESTIMATION OF TAMOXIFEN IN PHARMACEUTICAL PREPARATIONS AND ENVIRONMENTAL WASTEWATER SAMPLES

Nief Rahman Ahmed*, Najlaa Saadi Sheet and Mohammad Jassim Essa

ABSTRACT

A simple, accurate, precise, rapid, economical and high sensitive ultraviolet spectrophotometric method has been developed for the determination of Tamoxifen citrate in pharmaceutical preparations and environmental wastewater samples, which shows maximum absorbance at 235 nm in distilled water. Beer's law was obeyed in the range of 2.5-40μg/ ml, with molar absorptivity of 1.324x104 L.mol-1.cm-1, relative standard deviation of the method was less than 1.9%, and accuracy (average recovery %) was 100 ± 0. 8. No interference was observed from common excipients and additives often accompany with Tamoxifen citrate in pharmaceutical preparations. The method was successfully applied to the determination of Tamoxifen citrate in some pharmaceutical formulations (tablets) and industrial wastewater samples. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of Tamoxifen citrate in true samples.

Keywords: Tamoxifen, Spectrophotometry, Pharmaceutical Preparations, Environmental Samples.