A REVIEW ON ANTIEPILEPTIC ACTIVITY OF CENTELLA ASIATICA

Anagha V.*, Jerrin Jose K., Dr. Shijikumar P. S., Dr. Sirajudheen M. K. and Sherin A.

ABSTRACT

This present review on antiepileptic activity on centella asiatica focused on various experiments to demonstrate its antiepileptic activity compared to other antiepileptic drugs. Centella asiatica, commonly known as “gotu kola, Asiatic pennywort, Indian pennywort, wild violet, and tiger herb” a tropical plant, cultivated successfully due to its medical importance in some countries including turkey, and it has a utilization in ayurvedic and Chinese traditional medicines since centuries. From the various experiments, It is found that aqueous extract of centella asiatica contain constituents like triterpeniods, vitamins, aminoacids, Asiatic, asiaticoside, centellic, centoic and pectic acids which is responsible for antiepileptic activity. Centella asiatica also used different diseases like asthma, skin disorders, kidney troubles and elephantiasis etc. Since centella asiatica is important in epilepsy because of its longer duration of action and less adverse effect that compared to other antiepileptic drugs.

Keywords: Antiepileptic drugs, Centella asiatica, Maximal Electro Shock, Pentylenetetrazole, Tonic hind limb extension.