EVALUATION OF WOUND HEALING POTENTIAL OF VARIOUS WOUND HEALING CREAMS IN FRESH, DIABETIC AND BURN WOUND MODELS

Patil Pravin*, Nagore Dheeraj, Ambikar Digambar, Patil Manohar, Nipanikar Sanjay, Kanjilal Sanjeevan, Kanjilal Anisha

ABSTRACT

Introduction: The present study was designed to investigate comparative efficacy of various wound healing creams WHCs (F1 to F7) with placebo cream and marketed formulations (Mupirocin cream, Silver Sulfadiazine Cream and Jatyadi oil) using excision, incision and burn wound models in normal and diabetic rats. Materials and Methods: In-vivo excision, incision and burn wound models in normal and diabetic rats were used in order to assess comparative efficacy of various wound healing creams WHCs (F1 to F7) with marketed formulations. In case of the excision and burn wound models, wound contraction and period of epithelization were studied. Histopathological study was conducted in order to assess fibroblast proliferation, collagen formation, angiogenesis and epithelialization of wound. In incision wound model, tensile strength of wound was evaluated. Result: WHC [Formulation No. 4 (F-4)] showed significantly better wound healing activity than placebo cream, other various WHCs, Mupirocin Cream, Silver Sulfadiazine Cream and Jatyadi Oil. F-4 also showed complete epithelization and good collagen deposition as compared to Placebo Cream, other various WHCs, Mupirocin Cream, Silver Sulfadiazine Cream and Jatyadi Oil. Conclusion: F-4 showed statistically significant better wound healing activity in excision, incision and burn wound models in normal and diabetic rats as compared to placebo cream, other various WHCs, Mupirocin Cream, Silver Sulfadiazine Cream and Jatyadi Oil.

Keywords: Burn wound model, Excision Model, Incision Model, Wound healing potential, diabetic wound healing model, Silver Sulfadiazine Cream, Jatyadi Oil.