OVERVIEW OF PAPERS PUBLISHED ON THE FORMULATIONS OF OLANZAPINE API

Dr. Shubhangi C. Daswadkar* and Abhijit Vasant Atole

ABSTRACT

Olanzapine is an Antipsychotic drug used for the treatment of Schizophrenia disease. Nowadays Schizophrenia disease is increases day to day because of having very modern life. Olanzapine is a class II atypical Antipsychotic drug which having Low solubility and High permeability. Due to that, there bioavailability also decreases and so that the amount of drug which is required for the treatment of Schizophrenia cannot get. So for that reason there are some researchers worked on that disadvantage and tried to get a good bioavailability and hepatic first pass metabolism. For that purpose they discovered the new dosage forms like Olanzapine Injection, Olanzapine Tablets in that category there also different types such as Sustained release tablets, Orodispersible tablets, Matrix pellets, Sustained release matrix tablets, Mouth dissolving tablets, Micro emulsions, Polymeric Nanoparticles, Solid Lipid Nanoparticles, Quick dispersible tablets, Olanzapine Microspheres, Solid Dispersion. With using of that type of dosage forms they get good bioavailability and good hepatic first pass metabolism also get direct treatment to brain by brain targeting nanoparticles. The main objective of that review article is to provide information regarding the, which dosage forms are already prepared on Olanzapine API which are helpful to the students for the literature review in future.

Keywords: Antipsychotic, Olanzapine, Schizophrenia, bioavailability, Nanoparticles.