EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

FORMULATION AND IN-VITRO EVALUATION OF BILAYER TABLETS OF SUMATRIPTAN SUCCINATE

*B. Raja Narender and D. Meghana

ABSTRACT

The aim of this work was to design mucoadhesive bilayered buccal tablets of Sumatriptan succinate. Sumatriptan succinate is a serotonin 5-HT1 receptor agonist, used in treatment of migraine. It is absorbed rapidly but incompletely when given orally and undergoes first-pass metabolism, resulting in a low absolute bioavailability. Mucoadhesive polymers like xanthun gum and guar gum along with methyl crystalline cellulose were used for the preparation of mucoadhesive bilayered tablets. The optimized formulation followed Non-Fickian release mechanism. The percentage relative bioavailability of Sumatriptan succinate from selected bilayered buccal tablets was found to be 98.7%. Bilayered buccal tablets of Sumatriptan succinate was successfully prepared and evaluated with improved bioavailability.

Keywords: Sumatriptan succinate, bilayered buccal tablets, mucoadhesive polymers.

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