FORMULATION AND EVALUATION OF ORAL DISPERSIBLE TABLETS OF KETOROLAC TROMETHAMINE

M. Karthik*, Dr. G. Sandhya Rani, P. Swetha and D. Priyinaka

ABSTRACT

Oral disintegrating tablets of Ketorolac tromethamine were developed by using different disintegrants to avert the problem of swallowing and to provide rapid onset of action, which improves patient compliance and quality of life. The results of this study concluded that super disintegrants addition technique was an interesting way of formulating oral disintegrating tablets using direct compression technique which is easy, inexpensive and does not require special production equipment. Oral disintegrating tablets were formulated by using various disintegrants like sodium starch glycolate, Croscarmellose sodium & Crospovidone. The disintegrants were taken in concentrations of 5%, 10%, 15% and microcrystalline cellulose was used as diluent. Formulations F6 & F9 which contains 15% of Croscarmellose sodium & Crospovidone respectively along with microcrystalline cellulose showed least in- vitro disintegration time i.e., below 30 seconds and more than 90% drug release within 8 minutes. So, for the above formulations even in-vivo disintegration time and palatability (mouth feel) studies were carried out on healthy human volunteers.

Keywords: .