DESIGN AND DEVELOPMENT OF METOPROLOL SUSTAINED RELEASE MICROSPHERES

Anandas Sneha*

ABSTRACT

The study was aimed to Formulate Metoprolol sustained release microspheres. Microspheres were prepared by Ionic-Gelation method using Hydroxy Propyl Methyl Cellulose (HPMC), Eudragit S100and Ethyl cellulose for sustained release in view to prolong drug release. Metoprolol is an adreno receptor beta blocking agent used in the treatment of hypertension. It belongs to BCS class I drug means having high solubility and high permeability. Its biological half life ranges from 3 to 7 hours & oral bioavailability is 50% hence requires frequent oral administration for adequate treatment of hypertension. Conventional dosage form administration of Metoprolol has been reported to exhibit fluctuations in plasma drug levels resulting in either manifestation side effects or reduction in drug concentration at receptor site. Hence oral sustained dosage form of microspheres was developed. The microspheres were evaluated for various characteristics like encapsulation efficiency, percentage yield, partial size and the In vitro release. The Microspheres were found to be spherical, free-flowing, uniform in size and the microencapsulation efficiency was in the range of 87.4%.

Keywords: Microspheres, Hypertension, Metoprolol, Sustain release.