MODELLING THE THYROID CAUSING PROTEIN AND THEIR INHIBITOR STUDIES USING COMPUTATIONAL METHODS

*Pallavi Kaulwar and Prof. Archana Panche

ABSTRACT

Types of thyroid are. Causes of thyroid. Advantages by using some techniques or solutions for cure for thyroid. Disadvantages of thyroid. Drugs available for thyroid. Genes involved in thyroid. Receptors that play role during thyroid. Proteins that play role in thyroid disease are SIRT7- NAD dependent protein deacetylase that specifically mediates deacetylation of histone. GRB14- Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. RPS6KB1- Regulates protein synthesis. ABCA1- cAMP dependent and sulfonylurea, sensitive anioin transporter. SLC5A5/NIS protein- Mediates iodine uptake in the thyroid gland. BCL6- Play role in immunoglobulin. MRAS- May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. P21 Capsid protein- Regulate immune response and prevents destruction of infected cells by cytotoxic. Nef protein- Bypasses host T-cell signaling by inducing, cell activation.

Keywords: SIRT7- NAD, ABCA1- cAMP, SLC5A5/NIS.