NEONATAL SEPSIS DUE TO COAGULASE-NEGATIVE (CONS) STAPHYLOCOCCI: FREQUENCY, ANTIBIOTIC SUSCEPTIBILITY AND MOLECULAR CHARACTERIZATION BY 16S RNA ANALYSIS

*Budhlani G. N.

ABSTRACT

Sepsis is a significant cause of morbidity and mortality in neonates. Hence, the present study was undertaken to identify the frequent organism and to detect antibiotic sensitivity pattern against the isolated organism in respect to better treatment. In present investigation, Out of 1000 neonates who admitted to preterm unit and intensive care unit (ICU) from different hospitals in Akola city, 104(14.1%) neonates were blood culture positive. S.epidermidis (CONS) prevalent isolates amongst the gram positive organisms showed high rate of antibiotic sensitivity to Imipenem, Meropenem. In present investigation, antibiotic resistance of all isolates of S. epidermidis(CONS) was observed against Ampicillin and Penicillin. This study of S. epidermidis (CONS) causing neonatal sepsis and their sensitivity pattern is useful so that guidelines can be prepared for empirical antibiotic therapy.

Keywords: Neonatal Septicemia, Staphylococcus (CONS), Antibiotic sensitivity, 16s rRNA analysis.