EFFECT OF HYDRO ALCOHOLIC EXTRACT OF Vitis vinifera linn AGAINST DIMETHYL BENZ [A] ANTHRACENE INDUCED MAMMARY GLAND TUMOUR IN FEMALE SPARGUE-DAWLEY RATS

Bhuvaneswari B.*, Kishor J., Arya S.K., Chidambaranathan N.

ABSTRACT

The present study aimed that investigate the antitumor potential of hydro alcoholic extract of Vitis vinifera linn for 45 days against 7, 12-dimethyl Benz[a]anthracene (DMBA- 7.5mg/Kg) induced breast cancer in female Sprague- dawley rats. A treatment protocol started after DMBA administration. Results obtained displayed that there was a significant elevation in the terms of tumour incident and tumour multiplicity in DMBA injected rats. The potential reduction in tumour volume was observed in treatment groups whereas treated with HAEVV reverse these changes. The activities of superoxide dismutase, catalase, and glutathione peroxidase (free radical scavengers) were found to be escalated in treatment groups when compared to toxic control. Histopathological examination revealed the formation of tumour in DMBA induced rats. Whereas treatment with extract significantly decreased the proliferation and replacement of normal ductular and alveolar structure of mammary gland. Therefore it can be concluded that the HAEVV was provided antioxidant defense, with strong anti-tumour activity against DMBA- induced mammary tumours.

Keywords: Breast cancer, DMBA, Vitis vinifera linn, HAEVV.