SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NEW PYRIMIDINE ANALOGUES

Prabhudev S. M.*, Yasmeen B., Kishore Singh C., H. J. Kallur, Samina Sultana

ABSTRACT

In the present study, we focused on the environment-friendly processes used for the preparation of pyrimidine derivatives with pharmacological properties. In this regard, microwave heating is used as the alternative energy sources to synthesize a series of pyrimidine derivatives by the condensation of chalcones with urea under basic conditions. Chalcones were synthesized by Claisen-Schimidt condensation of acetophenone with various substituted benzaldehyde in the presence of ethanolic potassium hydroxide solution. The synthesized pyrimidine derivatives were characterized by IR, 1H NMR, Mass Spectra and CHN analyses confirmed the structure of the prepared compounds. The newly synthesized pyrimidine derivatives were screened for their antimicrobial & anthelmintic activity.

Keywords: Pyrimidine, Chalcone, Condensation, antimicrobial, anthelmintic activity.