EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Abstract

CHARACTERIZATION OF NEW METHYLATION MARKERS AND THE EXPRESSION OF GENES INVOLVED IN CARCINOGENESIS IN BREAST CANCER

*Alimkhodzhaeva L.T., Zakirova L.T., Nigmanova N.A. and Shamansurova N.S.

ABSTRACT

Modern oncology considers the RARβ2 gene as an important link in the pathogenesis of breast cancer and is being investigated as a new potential biomarker for breast cancer, in particular, a prognosis marker, tumor response to therapy, and metastasis. Point mutations of this gene are rare, but hypermethylation is observed in approximately 15% of breast cancer cases. The aim of this work was to evaluate RARβ2 hypermethylation in breast cancer and explain it from a biological point of view.

Keywords: breast cancer, RAR?2, breast cancer biomarker, hypermethylation.


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SJIF Impact Factor: 7.065

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