EVALUATION AND FORMULATION OF GEL FORM ANITDESMA VELUTINUM LEAVES EXTRACT FOR ANTIOXIDANT AND ANTI-WRINKLE ACTIVIES

Supachai Chumchuen*

ABSTRACT

Anitdesma velutinum (AV) has been used in Thai traditional medicine. The most antioxidant and anti-wrinkle properties were found on leaves. But the method in ancient has complicated. For ease of used, formulation of gel were the best answer. Objective: the study is to formulate and evaluate a topical herbal gel containing AV leaf extracts for their anti-oxidant and anti-wrinkles activities. Methods: The varies formulates of gels , concentration of extract. Activities for antioxidant tested DPPH method and anti-wrinkle processed by enzyme inhibitor of collagenase and elastase. Physiologicals were tested by oranoleptic, pH, viscosity etc and confirmed irritation on animal. Results: The herbal gel have concentrated 10 (% w/v) of extract was significantly p < 0.05, inhibiter enzyme for wrinkles and better stability than other formulation. Non detected irritation on rabbits. Conclusion: The gel formula with 10 % w/v has antioxidant activity and inhibit the enzymes for wrinkles, without irritation.

Keywords: Gel, Thai traditional medicine, Anti-wrinkle, Anti-oxidant.