“DESIGN, SYNTHESIS AND EVALUATION OF ANTI-DEPRESSANT ACTIVITY OF SOME NEW DERIVATVES OF PHENOTHIAZINE”

Nachiket S. Dighe*, Sanket K. Tambe, R B Saudagaur and Amol S Dighe

ABSTRACT

This study was aimed at the synthesis of fused Phenothiazine derivatives containing heterocyclic moiety.The synthesized compounds were tested for their preliminary tests, physical constants, TLC, IR, 1H-NMR Spectra and CHN analysis confirmed the structures of the final compounds.Antidepressant activity of all the synthesized compounds was evaluated by despair swim test by using Sprague Dawley Rats. Standard drug Imipramine was used as the control.In the despair swim test, all the synthesized derivatives showed antidepressant activity. Among them three Compounds (A7, A8, and A10) showed significant antidepressant activity comparing with control drug imipramine. These results are useful for the further investigation in the future.

Keywords: Antidepressant activities, Despair swim test, Phenothiazine and Sprague Dawley Rats.