EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Abstract

STATE OF THE CYTOKINE PROFILE AND APOPTOSIS FACTORS OF CHILDREN WITH DILATED CARDIOMYOPATHY

Kamalov Z. S.*, Aripova Sh. Sh., Achmedova D. I. and Sabirova F. B.

ABSTRACT

A clinical and immunological examination of 21 school children from 7 to 14 years old with dilated cardiomyopathy (DCMP) was carried out. As a control, 20 practically healthy children of comparable age were examined. Significant changes in the studied parameters of the immune system were found in children with DCMP. A significant increase in the concentration of pro-inflammatory (TNF-α and IL-18 increased by 4.2 and 3.0 times) cytokines was revealed. The number of expressing apoptosis antigen - CD95 + cells in peripheral blood rises 2.0 times.

Keywords: children, dilated cardiomyopathy, immunity, lymphocytes, apoptosis, cytokines.


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