NATTOKINASE ENZYME; AN EVALUATION OF ITS CELLULAR AND POTENTIAL THERAPEUTIC ACTIONS

Dr. Manoj G. Tyagi*

ABSTRACT

Fibrinolytic enzymes have been derived from different microorganisms, including the genus bacillus which occurs in traditional fermented foods. Nattokinase (NK) is an enzyme contained in the sticky component of natto, a cheese-like food made of soybeans fermented with Bacillus subtilis. Nattokinase has been shown to have fibrinolytic and has effects on the coagulation system which are beneficial for cardiovascular ailments. Recent research has shown that this enzyme may also have neuroprotective and also effects on the smooth muscle acvity with potential benefits for the Alzheimer’s disease, hypretension and vitreoretinal disorders. This review article focusses on the cellular and pharmacological actions of Nattokinase as well mentioning some experimental effects on gastrointestinal system.

Keywords: Nattokinase, fibrin, cardiovascular, smooth muscle, enzyme.