NANOEMULSION-BASED GEL FORMULATION OF LAMIVUDINE FOR TRANSDERMAL DELIVERY

Sushmitha A.* and Parthiban S.

ABSTRACT

Lamivudine is a anti-viral drug. The main purpose of the study is to develop nanoemulgel formulalation for transdermal delivery of Lamivudine using aloeveragel. The nanoemulsion can be prepared by using olive oil as oil phase and Tween-80 as surfactant and PEG 400 as co-surfactant were used in different ratio to determined by pseudoternary phase diagram. Four nanoemulsion were developed and coded as ON1, ON2, ON3, ON4 and the optimized formulation ON4 was converted into correponding gel by using Aloevera gel. The Lamivudine loded nanoemulsion were characterized by drug entrapment efficiency, pH, viscocity, transmittance and drug release, stability studies. Further, nanoemulgel formulation were evaluated by drug entrapment efficiency, pH, viscosity, drug release, stability studies. The nanoemulgel showed better release control and used for transdermal delivery of Lamivudine.

Keywords: Nanoemulgel, Lamivudine, transdermal delivery sytem.