A PROSPECTIVE STUDY ON THE EVALUATION OF HEPARIN AND ITS ANALOGUES UTILIZATION IN A TERITIARY CARE HOSPITAL

Fayiza A.*, Sreeja P. A., Ann Suvi David and Fabiya Ibrahim

ABSTRACT

The objective of the study was to evaluate the utilization of heparin and its analogues in a teritiary care hospital. The prospective study was carried out in a total of 81 patients treated with heparin and its analogues. Details of inpatients who were treated with heparin and analogues were collected from patient files. Evaluation of demographic data revealed that 58% (n=47) were males while 42% (n=34) were females. A high percentage of patients aged between 59-68 years were found in the study population. Laboratory monitoring analysis shows that APTT test and INR test was done for 58%(n=47) of the total populations. The most prominent indication for which it was prescribed as Stroke 34.5%(n=28). The most commonly prescribed heparin analogue was Unfractionated Heparin(UFH). The commonly preferred route for administration was subcutaneous route 62.9%(n=51). In prescription analysis, it was found that maximum number of patients was receiving 5000 U (61.7%, n=50) of unfractionated heparin via subcutaneous route. During study period, the adverse drug reactions associated with heparin use were identified and monitored using Naranjo Causality Assessment Scale, 42 patients(51.8%) shown Adverse Drug reactions in the total population. The most common Adverse Drug Reactions were pain at injection site(19%) and Thrombophlebitis(19%).

Keywords: UFH, LMWH, APTT, INR, subcutaneous route.