A COMPARITIVE STUDY ON INCIDENCE AND FREQUENCY OF HYPOGLYCEMIC MANIFESTATIONS IN PATIENTS WITH UNCONTROLLED TYPE 2 DM WITH AND WITHOUT COMPLICATIONS AT A TERTIARY CARE HOSPITAL

Sreelekshmi S.*, Prabhad Sankar, Ginsha Fahim and Sreeja P. A.

ABSTRACT

Objective: To compare the incidence of hypoglycemic manifestations in uncontrolled type 2 DM with and without complication. To identify the frequency of hypoglycemia in uncontrolled type 2 DM patients with and without complication. To assess the hypoglycemic manifestations using Naranjo causality assessment scale. Subjects with uncontrolled type 2 DM (n=101) were included in the analysis. If the patient showed any clinical manifestations in that instant gross random blood sugar was taken and confirmed hypoglycemia. P value of FBS and GRBS to be calculated by Graph pad prism version 8.4.0 (671). Distribution of uncontrolled type 2 DM with complication is (34.65%) and uncontrolled type 2 DM without complication is (65.34%). Male (55.45) gender is more susceptible to uncontrolled type 2 DM than female gender (44.55). The age group between 50-59 of uncontrolled type 2 DM with complication (31%) and uncontrolled type 2 DM without complication (30.6%). FBS of ≤70mg/dL to be noted and p value is 0.034. GRBS of ≤70mg/dL to be noted and p value is 0.047. Nephropathy (37.14%) is major complication in uncontrolled type 2 DM with complication. Incidence of hypoglycemia in uncontrolled type 2 DM with complication (51.42%) and in uncontrolled type 2 DM without complication (34.84%).only one episode of hypoglycemia occurred in both uncontrolled type 2 DM with complication (50%) and uncontrolled type 2 DM without complication (60.86%).clinical manifestations of hypoglycemia varies with patient to patient. Hypoglycemia in uncontrolled type 2 DM with complication caused by insulin (50%) and in uncontrolled type 2 DM without complication caused by OHA (52.17%).On assessing the ADR (hypoglycemia)in uncontrolled type 2 DM with complication is definite(77.77%) and in uncontrolled type 2 DM without complication also definite (65.21%).

Keywords: Uncontrolled type 2 diabetes mellitus, complications, incidence, frequency , clinical manifestations of hypoglycemia.