TO STUDY THE SLEEP ARCHITECTURE IN TREATMENT NAÏVE DEPRESSED PATIENTS WITH THE HELP OF POLYSOMNOGRAPHY BEFORE AND AFTER TREATMENT

*Dr. Harpreet Singh Dhillon, MD (Psychiatry), Dr. Ganesh Ingole, MD (Psychiatry), Dr. Bhupendra Yadav, MD (Psychiatry), Dr. Gurpreet Kaur Dhillon, MD (Paediatrics) and Lt. Col. Shibu Sasidharan

ABSTRACT

Background: A prospective cohort study to analyze the sleep architecture in treatment naïve depressed patients with the help of polysomnography before and after treatment. Methods: Patients were diagnosed for Depressive episode based on ICD-10 DCR. Psychometry, Beck Depressive inventory (BDI) was applied on Day 1 of admission. Polysomnography was conducted on Day 03 of admission after allowing patient to get accustomed to ward environment. Antidepressant treatment was started post Polysomnography. Post remission as indicated by adequate trial of antidepressants for 08 weeks and BDI score ≤09, Polysomnography was repeated. Statistical analysis was performed using Shapiro Wilk test, Kruskal Wallis test, Pearson correlation coefficient. Results: This study has shown positive findings (improvement) in terms of Total Sleep Time, Sleep Efficiency, Wake After Sleep Onset, Percentage Wake Time and these findings are statistically significant. Conclusion: Antidepressant treatment effectively improves sleep architecture in Depressive disorder and Polysomnography can become a useful tool to understand the course of illness and assess response.

Keywords: Antidepressants, Sleep Architecture, Depression, Polysomnography.