DEVELOPMENT AND CHARACTERIZATION OF ORAL DISINTEGRATING MINI -TABLET CONTAINING SALBUTAMOL SULPHATE BY SUBLIMATION METHOD

Sanjana S.* and Somashekhar C. N.

ABSTRACT

In pharmaceutical industry oral drug delivery is presently regarded as the most accepted route. But the main drawback of the oral dosage forms like delayed on set of action, difficulty in swallowing and poor patient compliance. The aim of the present investigation was to develop and evaluate the oral disintegrating mini-tablet (ODMT) of Salbutamol sulphate by sublimation method for the treatment of Asthma and Chronic pulmonary diseases (COPD). Immediate release tablets are highly accepted because rapid release drug delivery systems and thus, an attempt was made to improve the lag time, bioavailability and patience compliance. To reach this goal three different superdisintegrants were used namely Crospovidone, Sodium starch glycolate, and Croscarmellose Sodium used in different concentration (3 and 9%). Along with camphor used as a sublimating agent. Miromeritic properties of the powder blend were well within the limit confirmed by having good flow property and FTIR and DSC studies confirm the compatibility between drug and excipients and post formulation parameters were evaluated. Among the formulations F2 resulted a least disintegration and dissolution studies hence concluded that ODMTs give better effect to the asthma and COPD patients to improve the lag time, better patient compliance.

Keywords: Oral disintegrating tablets, Salbutamol sulphate, Superdisintegrants, Sublimation method.