EVALUATION OF ANTIULCER ACTIVITY OF MORINGA OLEIFERA PODS EXTRACT

*Sukanya Pramod Paricharak and Dr. Shivakumar Hugar

ABSTRACT

The aim of current study is to evaluate antiulcer activity of the 70% hydroalcoholic extract of Moringa oleifera pods (HAEMOP) using different animal models of ulcer in rats. Pylorus ligation method was studied using Ranitidine (150mg/Kg) in rats as reference standard. The ulcer index, pH of gastric juice, volume of gastric juice was determined. Ethanol and aspirin induced ulcer was studied and the ulcer index was measured. In antiulcer studies, Moringa oleifera pods extract showed reduction in ulcer score each experimental model sucessessfully. In pylorus ligation ulcer model it also reduced gastric volume and increased pH of gastric juice. The results have shown that the Moringa oleifera pods extract contain some active ingredients with the potential of being antiulcer agents.

Keywords: Moringa oleifera, Pylorus Ligation Ulcer, Ethanol, Aspirin, Ulcer Index.