CAFFEINATED ENERGY DRINK INDUCES OXIDATIVE STRESS, LIPID PEROXIDATION AND MILD DISTORTION OF CELLS IN THE RENAL CORTEX OF ADULT WISTAR RATS

Memudu, Adejoke Elizabeth*, Olarenwaju Ebun, Osahon, Itohan Roli and Oviosun, Augustine

ABSTRACT

Over the years, there has been an alarming increase in the production of different brands of caffeinated energy drink (ED) with different flavours that attracts the consumers with the aim of providing energy boost in their day to day activities. This study was conducted to effect of low and high doses ED on the renal histology system. Twenty-five adult male Wistar rats weighing 150-200 g were divided into five (5) experimental groups; Groups A: control, B treated with 2 ml ED, C treated with 2 ml energy drink and discontinued for 7 days, D treated with 4 ml ED, and E was treated with 4 ml energy drink and discontinued for 7 days. Histological analysis using haematoxylin and eosin, and PAS was conducted to ascertain the histoarchitectural integrity of the renal tissue. It was deduced from the study that caffeinated ED caused a significant increase in serum superoxide dismutase (SOD) level as compared with the control while MDA (malondialdehyde) serum activity increased as compared with control and withdrawal groups; increased in Bowman’s space, space, decreases the inner epithelial layer of the glomerulus as well as the epithelium of the proximal convoluted tubule. It was shown that ED consumption for a long time could affect the kidney by inducing oxidative stress and altering the histoarchitecture of the renal tissue. However, discontinuation of ED for 7 days shows positive potential of restoring the integrity of the renal cortex.

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