COMPARATIVE STUDY OF APP PROTEIN ASSOCIATED WITH ALZHEIMER’S DISEASE IN DIFFERENT ORGANISMS USING STRUCTURE PREDICTION METHOD (HOMOLOGY MODELING) AND ANALYSIS OF THEIR NETWORK PATHWAYS

Sumedh Choukidar, *Prasad Choukidar and Dr. Sanjay Harke

ABSTRACT

Comparative study in Bioinformatics is based on different aspects like sequence, structure and function which enhance the study. Protein structure prediction refers to generating 3 dimensional models from Amino acid sequence using computational algorithms. for structure analysis App protein has been targeted, plays a central role in the pathophysiology of Alzheimer’s disease. Further, we studied the network of ‘App’(Amyloid precursor protein) using STRING database as a study we took Different organism samples like Rattus norvegicus, Xenopus tropicalis, Mus Musculus and Homo sapiens. The aim of this paper to find the common protein associated with ‘App’ protein.

Keywords: App protein, Structure prediction, STRING Database.